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2 Glycogenolysis in liver, release of fatty acids from triglycerides in adipose tissue Stimulation screeening glucose uptake in muscle and adipose tissue, catabolism of car- bohydrates. Disease type Post-translational processing defect Trafficking defects of lysosomal enzymes Defect in lysosomal enzyme protection Defects in soluble non- enzymatic lysosomal proteins Transmembrane (non-enzyme) protein defect Disorder Multiple sulfatase deficiency Mucolipidosis type II (I-cell disease) Mucolipidosis type IIIA (pseudo- Hurlers) Mucolipidosis type IIIB Galactosialidosis NiemannPick disease C type 2 GM2 activator protein deficiency Sphingolipid activator protein deficiency Neuronal; ceroid lipofuscinosis (CNL5) Danons disease (LAMP-2 deficiency) NiemannPick disease C type 1 Cystinosis Infantile free sialic storage disease Sallas disease (free sialic acid storage) Juvenile ceroid lipofuscinosis (CNL3) Neuronal ceroid lipofuscinosis (CNL5) Neuronal ceroid lipofuscinosis (CNL6 and CNL8) Mucolipidosis type IV (mucolipin deficiency) Source: adapted from reference  148 language delay functional areas in the brain were based on study- ing screeening with language problems and then looking at their brains after death, Jacques.
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If the assay is carried out in vivo, then provided it has been carried out with satisfactory results on the final bulk vaccine, it may be omitted on the final lot.
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